Related Experiment Video
Updated: Jun 5, 2025

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
Published on: February 17, 2018
A case report of verapamil toxicity leading to haemodynamic compromise in obstructive hypertrophic cardiomyopathy
Jonathan W Gau1, Florian Rader2, Behram Mody3
1Department of Internal Medicine, School of Medicine, University of California, Irvine, 101 City Dr S, Orange, CA 92868, USA.
Insights
Verapamil toxicity can cause cardiogenic shock in hypertrophic cardiomyopathy (HCM) patients. Stopping the medication rapidly improved symptoms, highlighting the need for careful monitoring in HCM treatment.
Area of Science:
- Cardiology
- Pharmacology
- Genetics
Background:
- Hypertrophic cardiomyopathy (HCM) is an inherited cardiac condition.
- Left ventricular hypertrophy is a key characteristic, often with outflow tract obstruction.
- Verapamil is frequently prescribed for symptomatic relief in HCM patients.
Background:
Hypertrophic cardiomyopathy (HCM) is an inherited condition characterized by left ventricular (LV) hypertrophy unexplained by increased afterload, often with concomitant outflow tract obstruction. Verapamil is commonly used to treat symptomatic patients. However, its potential for adverse effects should be recognized.
Case Summary:
This report provides a case of cardiogenic shock in HCM, where a patient presented with chief complaint of fatigue and shortness of breath with an acute decline in LV systolic function on echocardiogram. His symptoms were attributed to verapamil toxicity following a recent increase in dosage. He achieved rapid symptom relief after holding his home medications, in addition to conservative management.
Discussion:
This case report aims to elucidate the potential for multiple adverse effects involved with verapamil use in patients with obstructive HCM.
More Related Videos
10:01High-Throughput Optical Controlling and Recording Calcium Signal in iPSC-Derived Cardiomyocytes for Toxicity Testing and Phenotypic Drug Screening
Published on: March 31, 2022
14:03High-Throughput Cardiotoxicity Screening Using Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Monolayers
Published on: March 24, 2023
Related Concept Videos
Imbalances in Cardiac Output
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers
Verapamil, a calcium channel blocker, inhibits calcium movement across myocardial cell membranes and vascular smooth muscle. This results in the dilation of coronary and...
Pathophysiology of Heart Failure
Heart Failure Drugs: Inotropic Agents
Mitral Regurgitation I: Introduction
Mitral Valve Prolapse II: Assessment and Management