Retrograde endovascular intervention treating chronic limb threatening ischemia: A case report
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Updated: May 4, 2026

Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia
Published on: June 8, 2019
Tran Minh Bao Luan1,2, Nguyen Huu Tuong3,2, Tran Quoc Han2
1Department of Thoracic and Vascular Surgery, University Medical Center HCMC, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam, 700000.
Abstract:
The retrograde approach is an adjunctive technique for endovascular intervention, particularly in the treatment of lower extremity arterial disease with multilevel vascular lesions. Combined with revascularization therapy, wound care plays a pivotal role in the management of patients with chronic limb-threatening ischemia. We present a case of chronic limb-threatening ischemia, with complex multilevel vascular lesions successfully treated using a retrograde endovascular approach alongside aggressive wound care management. Postintervention, the patient demonstrated a notable increase in ankle-brachial index from 0 to 1, along with accelerated wound healing and preservation of limb function. This case highlights the efficacy of the retrograde approach in restoring perfusion, particularly in chronic total occlusions, and emphasizes the importance of combining revascularization and wound care for optimal chronic limb-threatening ischemia management.
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