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Updated: Jun 5, 2025

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
Lung volume reduction: surgery versus endobronchial valves.
Laurens J Ceulemans1,2, Dorina Esendagli3, Giuseppe Cardillo4,5
1Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium.
Lung volume reduction surgery reshapes diseased lungs by removing damaged tissue, improving patient outcomes. Choosing between surgical or bronchoscopic lung volume reduction requires careful patient selection by a multidisciplinary team.
Area of Science:
- Pulmonology
- Thoracic Surgery
- Interventional Pulmonology
Background:
- Lung volume reduction is a disease-modifying treatment for emphysema.
- It aims to improve lung function, exercise tolerance, and quality of life.
- Key strategies include surgical lung volume reduction (VATS) and bronchoscopic lung volume reduction (BLVR).
Purpose of the Study:
- To highlight the importance of selecting the appropriate lung volume reduction strategy for optimal patient outcomes.
- To discuss factors influencing the choice between VATS and BLVR.
Main Methods:
- Review of current lung volume reduction techniques.
- Analysis of factors influencing procedural choice: emphysema distribution, collateral ventilation, pulmonary function tests, comorbidities, and prior interventions.
Main Results:
- Lung volume reduction is effective in well-selected patients.
- Patient-specific factors significantly impact the success of VATS versus BLVR.
Conclusions:
- The choice between VATS and BLVR depends on individual patient characteristics.
- A multidisciplinary expert team approach is crucial for optimal outcomes and minimizing complications in lung volume reduction procedures.
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