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Traditional Chinese medicine and its components effectively reduce resistance mediated by immune checkpoint

Mingxin Guo1, Wentong Fang2, Zhiqiang Hu1

  • 1Department of Pharmacy, The Affiliated Yixing Hospital of Jiangsu University, Yixing, China.

Frontiers in Immunology
|December 11, 2024
PubMed

Immunotherapy has become a global focus in cancer treatment and research, with promising results from targeting immune checkpoints in tumors like non-small cell lung cancer, colon cancer, and melanoma. However, resistance to immune checkpoint inhibitors (ICIs) remains a significant challenge. Traditional Chinese medicine (TCM), known for its low toxicity and minimal side effects, shows promise in enhancing cancer treatment when combined with modern therapies. This study reviews recent research on ICIs resistance mechanisms and highlights TCM's potential in overcoming this resistance, aiming to improve ICIs efficacy while minimizing toxicity.

Keywords:
Chinese herbsdrug resistanceimmune checkpoint inhibitorstraditional Chinese medicinetumor immunotherapy

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