Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

2.7K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.7K
Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

6.0K
Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
6.0K
Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

3.4K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
3.4K
Exocytosis00:51

Exocytosis

66.3K
Exocytosis is used to release material from cells. Like other bulk transport mechanisms, exocytosis requires energy.
66.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Effects of electroacupuncture at "Neiguan" (PC 6) on p38 MAPK signaling pathway in rats with cardiac hypertrophy].

Zhongguo zhen jiu = Chinese acupuncture & moxibustion·2012
Same author

Accurate measurement of oxygen consumption in children undergoing cardiac catheterization.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2012
Same author

Glutathione S-transferase polymorphisms and bone tumor risk in China.

Asian Pacific journal of cancer prevention : APJCP·2012
Same author

Systemic oxygen transport derived by using continuous measured oxygen consumption after the Norwood procedure-an interim review.

Interactive cardiovascular and thoracic surgery·2012
Same author

Discovery and optimization of 2,4-diaminoquinazoline derivatives as a new class of potent dengue virus inhibitors.

Journal of medicinal chemistry·2012
Same author

β(3)-Adrenoceptor Antagonist SR59230A Attenuates the Imbalance of Systemic and Myocardial Oxygen Transport Induced by Dopamine in Newborn Lambs.

Clinical Medicine Insights. Cardiology·2012

Related Experiment Video

Updated: Jun 5, 2025

Author Spotlight: Development of a Large-Scale, Reproducible Production Method for Exosome Mimetics Using Magnetic Nanoparticles
05:36

Author Spotlight: Development of a Large-Scale, Reproducible Production Method for Exosome Mimetics Using Magnetic Nanoparticles

Published on: January 26, 2024

1.3K

Exosomes and SARS-CoV-2 infection.

Liuying Li1,2, Zixuan Yang3, Jia Li3

  • 1Department of Traditional Chinese Medicine, Zigong First People's Hospital, Zigong, China.

Frontiers in Immunology
|December 11, 2024
PubMed
Summary
This summary is machine-generated.

Exosomes, tiny vesicles, play key roles in SARS-CoV-2 infection by aiding viral spread and immune evasion. They offer potential as diagnostic markers and therapeutic targets for COVID-19.

Keywords:
COVID-19SARS-CoV-2exosomesimmunoregulationinterplay

More Related Videos

Purification of High Yield Extracellular Vesicle Preparations Away from Virus
00:07

Purification of High Yield Extracellular Vesicle Preparations Away from Virus

Published on: September 12, 2019

11.4K
Direct Stochastic Optical Reconstruction Microscopy of Extracellular Vesicles in Three Dimensions
09:36

Direct Stochastic Optical Reconstruction Microscopy of Extracellular Vesicles in Three Dimensions

Published on: August 26, 2021

3.7K

Related Experiment Videos

Last Updated: Jun 5, 2025

Author Spotlight: Development of a Large-Scale, Reproducible Production Method for Exosome Mimetics Using Magnetic Nanoparticles
05:36

Author Spotlight: Development of a Large-Scale, Reproducible Production Method for Exosome Mimetics Using Magnetic Nanoparticles

Published on: January 26, 2024

1.3K
Purification of High Yield Extracellular Vesicle Preparations Away from Virus
00:07

Purification of High Yield Extracellular Vesicle Preparations Away from Virus

Published on: September 12, 2019

11.4K
Direct Stochastic Optical Reconstruction Microscopy of Extracellular Vesicles in Three Dimensions
09:36

Direct Stochastic Optical Reconstruction Microscopy of Extracellular Vesicles in Three Dimensions

Published on: August 26, 2021

3.7K

Area of Science:

  • Cell biology
  • Virology
  • Immunology

Background:

  • Exosomes are small extracellular vesicles crucial for intercellular communication.
  • They carry proteins, lipids, and nucleic acids influencing immune responses and disease.
  • Exosomes are implicated in SARS-CoV-2 transmission, immune evasion, and pathogenesis.

Purpose of the Study:

  • To review the role of exosomes in the host-virus interaction during SARS-CoV-2 infection.
  • To highlight the potential of exosomes as biomarkers and therapeutic targets for COVID-19.

Main Methods:

  • Literature review of current research on exosomes and SARS-CoV-2.
  • Analysis of studies investigating exosome involvement in viral pathogenesis and host response.

Main Results:

  • Exosomes contribute to SARS-CoV-2 transmission and immune escape.
  • Exosome cargo influences viral pathogenesis and host immune regulation.
  • Exosomes show promise as diagnostic and therapeutic tools for COVID-19.

Conclusions:

  • Exosomes are significant mediators in SARS-CoV-2 infection.
  • Targeting exosomes may offer novel strategies for COVID-19 diagnosis and treatment.