Radiomics predicting immunohistochemical markers in primary hepatic carcinoma: Current status and challenges.

Area of Science:

• Oncology
• Medical Imaging
• Biomarker Research

Background:

• Primary hepatic carcinoma, including hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), and combined hepatocellular cholangiocarcinoma (cHCC-CCA), is a globally prevalent and heterogeneous malignancy.
• Tumor heterogeneity significantly challenges treatment efficacy, necessitating advanced methods for characterization.
• Current immunohistochemical analysis relies on invasive biopsies, highlighting the need for non-invasive preoperative assessment.

Purpose of the Study:

• To explore the application of radiomics in predicting immunohistochemical markers for primary hepatic carcinoma.
• To assess radiomics' potential in characterizing tumor heterogeneity non-invasively.
• To provide insights into personalized treatment strategies for primary hepatic carcinoma.

Main Methods:

• Utilizing radiomics, a non-invasive imaging technique, to analyze primary hepatic carcinoma.
• Correlating radiomic features with immunohistochemical markers.
• Reviewing current research progress and challenges in radiomics for hepatic cancer.

Main Results:

• Radiomics shows potential in predicting immunohistochemical markers preoperatively.
• This predictive capability can assist in characterizing tumor heterogeneity.
• Radiomics offers auxiliary utility for clinical guidance in managing primary hepatic carcinoma.

Conclusions:

• Radiomics is a promising non-invasive tool for predicting immunohistochemical markers in primary hepatic carcinoma.
• It aids in understanding tumor heterogeneity and supports personalized medicine.
• Further research is needed to overcome challenges and expand its clinical application.