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High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum
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The therapeutic effect of ofatumumab in pediatric anti-NMDAR encephalitis: A case series

Wenlin Wu1, Jie Hong1, Yanping Ran1

  • 1Department of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, China.

Heliyon
|December 11, 2024
PubMed

Insights

Ofatumumab (OFA) offers a safe and effective treatment for pediatric anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. This anti-CD20 antibody therapy improved symptoms and achieved B cell depletion in patients resistant to initial treatments.

Area of Science:

  • Neurology
  • Immunology
  • Pediatrics

Background:

  • Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a severe autoimmune neurological disorder.
  • Pediatric patients often face challenges with first-line immunotherapy, necessitating alternative treatment strategies.

Keywords:
Anti-NMDAR encephalitisChildrenOfatumumabRefractory

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