Two Cases of Intraocular Undifferentiated Pleomorphic Sarcoma

Area of Science:

• Oncology
• Ophthalmology
• Pathology

Background:

• Undifferentiated pleomorphic sarcoma (UPS), previously known as malignant fibrous histiocytoma, is a high-grade soft tissue sarcoma originating from mesenchymal stem cells.
• UPS constitutes approximately 5% of all soft tissue sarcomas, with head and neck presentations being particularly rare (1-3% of all UPS cases).

Observation:

• This report details two instances of intraocular UPS in 68-year-old males.
• One patient developed UPS in an eviscerated socket following chronic fibrinous inflammation.
• The second patient's UPS developed years after experiencing ocular trauma.

Findings:

• Both reported cases of intraocular UPS were associated with a history of chronic inflammation and ocular trauma.
• These cases support the hypothesis linking chronic inflammation to sarcoma formation.

Implications:

• The findings highlight the potential role of chronic inflammation in the pathogenesis of undifferentiated pleomorphic sarcoma.
• Further research into the inflammatory pathways involved in sarcoma development is warranted.