The gut microbiota genus Blautia is associated with skeletal muscle mass reduction in community-dwelling older Japanese adults: the Wakayama Study
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View abstract on PubMed
Summary
This summary is machine-generated.Higher levels of the gut bacterium Blautia were linked to reduced muscle mass in older adults. Modulating gut microbiota could help preserve skeletal muscle in aging populations.
Area Of Science
- Gerontology
- Microbiome research
- Nutritional science
Background
- Sarcopenia, or age-related muscle mass loss, is a significant health concern in older adults.
- The gut microbiota plays a crucial role in host metabolism and health, but its association with sarcopenia is not fully understood.
Purpose Of The Study
- To investigate the relationship between gut microbiota composition and skeletal muscle mass in elderly Japanese individuals.
- To identify specific gut microbial species associated with reduced appendicular skeletal muscle mass (ASM).
Main Methods
- Cross-sectional study of 744 community-dwelling Japanese adults (aged 65-89).
- Appendicular skeletal muscle mass (ASM) assessed via bioelectrical impedance analysis.
- Gut microbiota composition analyzed using 16S rRNA gene sequencing.
- Dietary and lifestyle factors evaluated through questionnaires.
Main Results
- Participants with reduced muscle mass exhibited significantly higher levels of the bacterial genus Blautia compared to those with normal muscle mass (P=0.009).
- The association between Blautia and lower muscle mass remained significant after adjusting for confounders (P=0.012).
- Increased Blautia levels correlated positively with excessive alcohol consumption and negatively with regular yogurt intake.
Conclusions
- Elevated Blautia genus levels are associated with reduced skeletal muscle mass in older Japanese adults.
- Targeting and improving gut microbiota composition may represent a novel strategy for preserving muscle mass in aging populations.
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