The Association Between Patient-Reported Outcomes and Surgical Attrition During Neoadjuvant Therapy for Gastrointestinal Malignancies
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View abstract on PubMed
Summary
This summary is machine-generated.Neoadjuvant therapy for GI/HPB cancers can lead to surgical attrition. Cancer type, comorbidities, and complications, not quality of life, predict failure to undergo surgery.
Area Of Science
- Oncology
- Surgical Oncology
- Gastroenterology
Background
- Neoadjuvant therapy (NT) is increasingly utilized for gastrointestinal (GI) and hepatopancreatobiliary (HPB) cancers.
- Understanding risk factors for surgical attrition after NT is crucial for patient management.
Purpose Of The Study
- To identify factors associated with surgical attrition in patients undergoing neoadjuvant therapy for GI/HPB cancers.
- To analyze patient-reported outcomes (PROs) as potential predictors of surgical attrition.
Main Methods
- A prospective cohort study analyzed data from 104 adult patients receiving NT for GI/HPB cancer.
- Patient-reported outcomes (PROs) and quality of life (QOL) were assessed via a mobile application.
- Logistic regression models identified associations between demographic, clinical characteristics, and PROs with surgical attrition (no surgery vs. surgery/watchful waiting).
Main Results
- Of 104 patients, 27% did not undergo surgery (NS) after NT.
- Hepatopancreatobiliary (HPB) cancer type (OR 7.0), comorbidities (OR 1.72), and severe complications during NT (OR 4.2) were associated with NS.
- Lack of appetite was the only PRO associated with NS (OR 3.6), while overall QOL and other PROs did not differ between surgical groups.
Conclusions
- Neoadjuvant therapy for GI/HPB malignancies is associated with surgical attrition.
- Cancer type, comorbidities, and severe complications during NT are key predictors of failure to undergo surgery.
- Patient-reported outcomes and quality of life are largely not associated with surgical attrition, except for appetite.
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