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Related Concept Videos

Transformers01:26

Transformers

A device that transforms voltages from one value to another using induction is called a transformer. A transformer consists of two separate coils, or windings, wrapped around the same soft iron core. However, they are electrically insulated from each other.
The iron core has a substantial relative permeability. Therefore, the magnetic field lines generated due to the current in one winding are almost entirely confined within the core, such that the same magnetic flux permeates each turn of both...

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Related Experiment Video

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Imaging-guided bioresorbable acoustic hydrogel microrobots.

Hong Han1, Xiaotian Ma1, Weiting Deng1,2

  • 1Andrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.

Science Robotics
|December 11, 2024
PubMed
Summary
This summary is machine-generated.

We developed a bioresorbable acoustic microrobot (BAM) for stable navigation and targeted delivery within the body. This hydrogel-based robot uses ultrasound for imaging and control, ensuring safe, effective biomedical applications.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Robotics

Background:

  • Micro- and nanorobots offer potential for in vivo diagnostics and therapeutics.
  • Challenges include stable propulsion, deep-tissue imaging, and precise control in biological environments.

Purpose of the Study:

  • To introduce a novel hydrogel-based, imaging-guided, bioresorbable acoustic microrobot (BAM).
  • To address limitations in current microrobot technology for in vivo applications.

Main Methods:

  • BAMs constructed via two-photon polymerization with magnetic nanoparticles and therapeutic agents.
  • Optimized surface chemistry (hydrophobic inner, hydrophilic outer) for microbubble retention and biocompatibility.
  • Dual-opening bubble-trapping cavity for acoustic propulsion in diverse biofluids.
  • Focused ultrasound stimulation for imaging and wireless magnetic navigation.

Main Results:

  • BAMs demonstrated stable propulsion and multiday functionality in biofluids.
  • Real-time ultrasound imaging facilitated precise tracking and control of BAMs.
  • Hydrolysis-driven biodegradability confirmed safe dissolution post-treatment.
  • In vitro and in vivo experiments validated BAM capabilities.

Conclusions:

  • BAMs represent a promising advancement for minimally invasive medical interventions.
  • This technology enhances targeted therapeutic delivery with improved safety and efficacy.