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Published on: August 7, 2017
Dynamic indicators of the antioxidant system in children with acute respiratory pathology depending on the therapy
Olesya M Horlenko1, Iryna Yu Pikina1, Lyubomyra B Prylypko1
1UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE.
Insights
This study investigated the antioxidant system in children with acute respiratory infections, finding that optimized therapy improved levels of Glutathione peroxidase, Ascorbic acid, and Vitamin D, alongside beneficial trace element changes.
Area of Science:
- Pediatric Pulmonology
- Immunology
- Biochemistry
Background:
- Acute respiratory infections (ARIs) pose a significant health challenge in children.
- Early diagnosis and effective management of ARIs are crucial for preventing severe outcomes.
- The role of the antioxidant system (AOS) in pediatric ARIs requires further elucidation.
Purpose of the Study:
- To enhance the early diagnosis and prediction of ARI development in children.
- To assess the impact of the antioxidant system's state on ARI course and outcomes.
- To evaluate the effectiveness of optimized therapeutic strategies on AOS markers and clinical parameters.
Main Methods:
- A cohort of school-aged children (10-14 years) diagnosed with ARIs (n=111) was studied.
- A control group of healthy children (n=25) was included for comparison.
- Correlations between AOS components (ferritin, cortisol, ascorbic acid, vitamin D) and inflammatory markers (TNF-α, IL-6, IL-2, γ-IFN) were analyzed.
Main Results:
- Significant positive correlations were observed between ferritin and TNF-α, and cortisol and Glutathione peroxidase.
- Ascorbic acid showed positive interactions with IL-6 and IL-2, while vitamin D correlated with γ-IFN, leptin, and copper.
- Optimized therapy led to a significant increase in Glutathione peroxidase, Ascorbic acid, and normalized Vitamin D levels, with positive effects on copper, zinc, and iron.
Conclusions:
- The antioxidant system plays a critical role in the pathogenesis and recovery from pediatric ARIs.
- Optimized therapeutic approaches significantly improve AOS status and clinical outcomes in children with ARIs.
- Monitoring AOS markers can aid in early diagnosis, prognosis, and personalized treatment strategies for pediatric respiratory infections.
Objective:
Aim: To improve the early diagnosis, course, prediction of the development of Acute Respiratory pathology in children, taking into account the state of antioxidant system (AOS).
Patients And Methods:
Materials and Methods: The research group included school-age children (10-14 years old) with Acute Respiratory pathologe (n=111) and a control group (n=25).diseases in comparation.
Results:
Results: The highest positive correlation between ferritin and TNF- α (r=0,41, p=0,001); Cortisol with Glutathione peroxidase (r=0,35, p=0,006) were observed. Ascorbic acid presented positive interactions on the values of Il-6 and Il-2 (r=0,27, 0,26, respectively). The value of vitamin D is represented in positive interactions with γ-IFN (r=0,30), leptin (r=0,38) and Cu (r=0,32). The negative relationship of Zn with Il-6 was transformed for supporting immune barriers and protein metabolism.
Conclusion:
Conclusions: The level of Glutathione peroxidase increased in 1,6 times, on the other hand, when the basic therapy was prescribed - in 1,1 times (р3<0,01; р4<0,01; р5<0,01), cortisol level had a reliable tendency to decrease in 1,6. The values of Ascorbic acid increased by almost in 2 times in first group andin 1,4 times in the second group ( p3<0,01; p4<0,01; p5<0,01). After the treatment, the level of vitamin D was identified within the physiological range in the first group. There are also positive effects of optimized therapy on the state of Copper (p3<0,01), Zinc (p3<0,01), Iron (p3=0,04) trace elements in comparison with the data of the second group.
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