Comparative Analysis of Generative Pre-Trained Transformer Models in Oncogene-Driven Non-Small Cell Lung Cancer:...

Precision oncology in non-small cell lung cancer (NSCLC) relies on biomarker testing for clinical decision making. Despite its importance, challenges like the lack of genomic oncology training, nonstandardized biomarker reporting, and a rapidly evolving treatment landscape hinder its practice. Generative artificial intelligence (AI), such as ChatGPT, offers promise for enhancing clinical decision support. Effective performance metrics are crucial to evaluate these models' accuracy and their propensity for producing incorrect or hallucinated information. We assessed various ChatGPT versions' ability to generate accurate next-generation sequencing reports and treatment recommendations for NSCLC, using a novel Generative AI Performance Score (G-PS), which considers accuracy, relevancy, and hallucinations.

We queried ChatGPT versions for first-line NSCLC treatment recommendations with an Food and Drug Administration-approved targeted therapy, using a zero-shot prompt approach for eight oncogenes. Responses were assessed against National Comprehensive Cancer Network (NCCN) guidelines for accuracy, relevance, and hallucinations, with G-PS calculating scores from -1 (all hallucinations) to 1 (fully NCCN-compliant recommendations). G-PS was designed as a composite measure with a base score for correct recommendations (weighted for preferred treatments) and a penalty for hallucinations.

Analyzing 160 responses, generative pre-trained transformer (GPT)-4 outperformed GPT-3.5, showing higher base score (90% v 60%; P < .01) and fewer hallucinations (34% v 53%; P < .01). GPT-4's overall G-PS was significantly higher (0.34 v -0.15; P < .01), indicating superior performance.

This study highlights the rapid improvement of generative AI in matching treatment recommendations with biomarkers in precision oncology. Although the rate of hallucinations improved in the GPT-4 model, future generative AI use in clinical care requires high levels of accuracy with minimal to no room for hallucinations. The GP-S represents a novel metric quantifying generative AI utility in health care compared with national guidelines, with potential adaptation beyond precision oncology.