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Distribution and Drug Resistance of Pathogens of Catheter-Related Blood Stream Infection in a Hospital from 2017 to
Insights
Catheter-related bloodstream infections (CRBSI) are often caused by coagulase-negative Staphylococcus. Gram-negative bacilli show high drug resistance, necessitating standardized antibiotic use and enhanced monitoring of multidrug-resistant bacteria in hospitals.
Area of Science:
- Clinical microbiology
- Infectious diseases
- Hospital epidemiology
Background:
- Retrospective analysis of pathogens causing catheter-related bloodstream infections (CRBSI).
- Evaluation of antibiotic susceptibility patterns for CRBSI pathogens over a five-year period.
Purpose of the Study:
- To determine the clinical distribution of CRBSI pathogens.
- To assess the antibiotic susceptibility profiles of isolated pathogens.
- To inform strategies for infection control and antibiotic stewardship.
Main Methods:
- Data collected retrospectively from January 2017 to December 2021.
- Pathogen identification and antibiotic susceptibility testing performed using VITEK-2 Compact.
- Data analysis conducted with WHONET 5.6 software.
Main Results:
- Coagulase-negative Staphylococcus (64.5%) was the most common CRBSI pathogen, followed by Enterococcus (4.3%) and Staphylococcus aureus (2.9%).
- Staphylococci and Streptococci showed sensitivity to Linezolid, Vancomycin, Quinuprine/Dafuprine, and Tigecycline.
- Gram-negative bacilli (28.3%), including Klebsiella pneumoniae, Acinetobacter baumannii, and Burkholderia cepacia, exhibited high drug resistance rates (>50%).
- CRBSI pathogens were predominantly isolated from Peritoneal Tumor Surgery (62.3%) and ICU (14.5%) departments.
Conclusions:
- The rise of multidrug-resistant (MDR) bacteria underscores the need for enhanced prevention and control of nosocomial infections.
- Standardization of antibiotic use and management is crucial.
- Strengthening the monitoring of MDR bacteria within hospitals is recommended.
Background:
We analyzed the clinical distribution and the antibiotic susceptibility of pathogens for catheter-related blood stream infection (CRBSI) in the hospital retrospectively.
Methods:
The clinical information and pathogens associated with CRBSI were collected from the Microbiology Laboratory of the hospital retrospectively from January 2017 to December 2021. Identification and the antibiotic susceptibility test (AST) were carried out with VITEK-2 Compact. The data were analyzed by WHONET 5.6.
Results:
A total of 138 isolates (6.4%) associated with CRBSI were found during the 5-year period. Among the pathogens of CRBSI, 89 (64.5%) isolates were coagulase-negative Staphylococcus, 6 (4.3%) were strains of Enterococcus, and 4 (2.9%) were strains of Staphylococcus aureus. Staphylococci and Streptococci were all sensitive to Linezolid, Vancomycin, Quinuprine/Dafuprine, and Tigecycline. There were 39 (28.3%) Gram-negative bacilli isolates, including 17 strains of Klebsiella pneumoniae (12.3%), 6 (4.3%) strains of Acinetobacter baumannii, and 6 (4.3%) strains of Burkholderia cepacia. The drug resistance rates of Gram-negative bacilli to most drugs were higher than 50%. The main departments where CRBSI pathogens were isolated were Peritoneal Tumor Surgery (86, 62.3%), ICU (20, 14.5%), Emergency Department (6, 4.3%), and Respiratory Department (6, 4.3%).
Conclusions:
With the emergence of multidrug-resistant (MDR) bacteria, more attention should be paid to the prevention and control of nosocomial infections. At the same time, the use and management of antibiotics should be standardized, and monitoring of multidrug-resistant bacteria should be strengthened in hospitals.
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