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Neurotoxic esterase in rooster testis.

M Lotti, E T Wei, R C Spear

    Toxicology and Applied Pharmacology
    |January 1, 1985
    PubMed
    Summary
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    Neurotoxic esterase (NTE) activity was found in rooster testes, showing faster recovery after organophosphate exposure than brain tissue. This suggests the testes may be less susceptible to delayed neuropathy.

    Area of Science:

    • Toxicology
    • Neuroscience
    • Biochemistry

    Background:

    • Organophosphorus compounds can cause delayed neurotoxicity.
    • Neurotoxic esterase (NTE) is the suspected target protein for this toxicity.
    • The presence and role of NTE in reproductive organs are not well understood.

    Purpose of the Study:

    • To investigate the presence and characteristics of NTE in rooster testes.
    • To compare the effects of organophosphorus compounds on testicular NTE versus brain NTE.
    • To assess potential testicular pathology and hormonal changes following organophosphate exposure.

    Main Methods:

    • Biochemical assays to measure NTE activity in rooster testes.
    • In vitro and in vivo inhibition studies using organophosphorus compounds.

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  • Subcellular fractionation to determine NTE localization.
  • Histopathological examination and serum testosterone level measurements.

    • Main Results:

    • NTE activity was confirmed in rooster testes, with a portion resistant to paraoxon.
    • Testicular NTE was inhibited by organophosphorus compounds in vitro and in vivo, but less so than brain NTE.
    • No testicular pathology was observed, and serum testosterone levels remained normal after exposure.
    • Testicular NTE activity recovered more rapidly than brain NTE activity post-exposure.

    Conclusions:

    • Rooster testes possess functional NTE.
    • Testicular NTE is less sensitive to organophosphate inhibition and recovers faster than brain NTE.
    • Organophosphorus-induced delayed neuropathy does not appear to cause significant testicular damage or alter testosterone levels in roosters.