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EOMES establishes mesoderm and endoderm differentiation potential through SWI/SNF-mediated global enhancer remodeling

Chiara M Schröder1, Lea Zissel2, Sophie-Luise Mersiowsky3

  • 1Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany; Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, Germany; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany.

Developmental Cell
|December 11, 2024
PubMed
Summary

The Tbx factor Eomes globally opens enhancers for mesendoderm (ME) lineage commitment in mouse stem cells. Eomes and the SWI/SNF complex rewire chromatin, overcoming default neuroectoderm (NE) differentiation.

Keywords:
EomesSWI/SNF complexTbx factorscell fate decisionchromatin accessibilityenhancer regulationepigenetic remodelinggastrulation

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