Extraction, purification, structural characterization, biological activity, mechanism of action and application of...

Ganoderma lucidum is a traditional tonic medicine in China, known as the "fairy grass" and "spiritual grass". It contains various chemical components, such as polysaccharides, triterpenoids, alkaloids, nucleosides, sterols, and acid compounds, which have the effects of tonifying qi and calming the mind, stopping cough and asthma, and are used to treat restlessness, lung deficiency cough and asthma, fatigue and shortness of breath, and lack of appetite. Ganoderma lucidum polysaccharides (GLPs) are one of the main bioactive ingredients and are widely used in traditional Chinese medicine and traditional medicine fields. They have shown good medicinal value in enhancing immunity, inhibiting tumor cell growth, delaying aging, lowering blood sugar, lowering blood lipids, protecting the heart, anti-radiation, anti-fatigue, and other aspects. This article reviews the research progress on the extraction and purification, structural characteristics, pharmacological activity, and mechanisms of GLPs, as well as their applications in industries such as medicine, food, and daily chemical products. The aim is to provide theoretical basis for the treatment of traditional Chinese medicine compound preparations and lay the foundation for the potential value development of Ganoderma lucidum products.