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Not only the top: Type I topoisomerases function in multiple tissues and organs development in plants
Hao Zhang1, Lirong Tian1, Yuru Ma1
1Ministry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Research Center of the Basic Discipline of Cell Biology, Hebei Collaboration Innovation Center for Cell Signaling and Environmental Adaptation, Hebei Key Laboratory of Molecular and Cellular Biology, College of Life Sciences, Hebei Normal University, 050024, Shijiazhuang, China.
Journal of Advanced Research
|December 11, 2024
Summary
Plant DNA topoisomerases type I (TOP1s) are crucial for development and gene transcription. This review summarizes their diverse functions and mechanisms in plants, highlighting recent research progress and future directions.
Area of Science:
- Plant molecular biology
- Enzymology
- Genetics
Background:
- DNA topoisomerases (TOPs) are vital for DNA replication, transcription, and genome integrity.
- While extensively studied in other organisms, plant TOP1 research is relatively new.
- Plant TOP1s are essential enzymes involved in numerous developmental processes.
Purpose of the Study:
- To review the function and mechanism studies of plant TOP1s.
- To present the structural biology of plant TOP1.
- To discuss future research directions for plant TOP1s.
Main Methods:
- Literature review of published research on plant TOP1s.
- Analysis of studies on TOP1 function and mechanism in various plant tissues.
- Examination of structural biology data for plant TOP1.
Main Results:
- Plant TOP1s play critical roles in meristem activity, gametogenesis, flowering time, and gravitropism.
- TOP1s influence gene transcription by modulating chromatin accessibility, DNA/RNA structure, and nucleosome positioning.
- This review consolidates current knowledge on plant TOP1s, which is less summarized than in other species.
Conclusions:
- Plant TOP1s are essential enzymes with diverse roles in plant development and gene regulation.
- Further research is needed to fully elucidate the working mechanisms of plant TOP1s.
- Understanding plant TOP1s provides insights into fundamental biological processes in plants.
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