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Alternative Antibiotic Selections During the 2022 Amoxicillin Shortage in the United States

Sriram Ramgopal1,2,3, Marc Rosenman2,3,4, Lu Zhang3,5

  • 1Division of Emergency Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Journal of the Pediatric Infectious Diseases Society
|December 11, 2024
PubMed

Insights

The 2022 amoxicillin shortage decreased amoxicillin suspension prescriptions by 30.8%, leading to more use of other forms and broad-spectrum antibiotics. Strategic planning is crucial for managing future drug shortages effectively.

Area of Science:

  • Pediatric Pharmacy
  • Infectious Disease Management
  • Drug Shortage Preparedness

Background:

  • The 2022 amoxicillin shortage impacted pediatric prescribing practices.
  • Availability of essential antibiotics is critical for patient care.

Purpose of the Study:

  • To analyze the impact of the 2022 amoxicillin shortage on antibiotic prescribing in pediatric hospitals.
  • To evaluate changes in the utilization of amoxicillin formulations and broad-spectrum antibiotics during the shortage.

Main Methods:

  • Retrospective analysis of prescribing data from 7 pediatric hospitals.
  • Comparison of antibiotic utilization patterns before and during the amoxicillin shortage period.

Main Results:

  • A significant 30.8% decline in amoxicillin suspension prescribing was observed.
  • There was a 7.9% increase in the use of amoxicillin nonsuspension formulations.
  • An increase in the prescription of broad-spectrum antibiotics was noted.

Conclusions:

  • The amoxicillin shortage led to significant shifts in pediatric antibiotic prescribing.
  • Strategic planning and standardized guidelines are necessary to mitigate the effects of future drug shortages.
  • Ensuring guideline-based care during shortages requires proactive measures and adaptable strategies.
Keywords:
amoxicillinantimicrobial stewardshippediatricrespiratory infectionsshortage

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