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Identification of the Novel HLA-DPA1*02:143 Allele by Next-Generation Sequencing
Jong Kwon Lee1, Sohyeon Eom1, Jun Woo Park1
1Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
HLA
|December 12, 2024
Summary
A novel HLA-DPA1 allele, HLA-DPA1*02:143, was identified. It differs from HLA-DPA1*02:02:02:01 by only one nucleotide substitution in exon 1.
Area of Science:
- Immunogenetics
- Molecular biology
Background:
- The human leukocyte antigen (HLA) system is crucial for immune response.
- Polymorphisms in HLA genes contribute to immune diversity and disease susceptibility.
Purpose of the Study:
- To characterize a newly identified HLA-DPA1 allele.
Main Methods:
- Sequence analysis of the HLA-DPA1 gene.
- Comparison with known HLA-DPA1 alleles.
Main Results:
- A novel allele, designated HLA-DPA1*02:143, was discovered.
- This allele is identical to HLA-DPA1*02:02:02:01 except for a single nucleotide substitution in exon 1.
Conclusions:
- The identification of HLA-DPA1*02:143 expands the known HLA-DPA1 allele repertoire.
- This finding contributes to a more comprehensive understanding of HLA polymorphism.
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