Related Experiment Video
Updated: Jun 5, 2025

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
Denosumab-Induced Recurrent Severe Hypocalcaemia in a Patient With Chronic Kidney Disease: A Case Report
Rujina Begum1, Summon Mir2, Brian Lee3
1Emergency Medicine, Midland Metropolitan University Hospital, Birmingham, GBR.
Abstract:
Denosumab is a human monoclonal immunoglobulin G2 (IgG2) antibody that is used in the management of osteoporosis and various bone-related disorders to help strengthen bones and prevent fractures. Declining renal function and the drug denosumab are both associated with an increased risk of hypocalcaemia. The combination of both factors in a patient, along with the long half-life of the drug, can cause further exacerbation of this risk. A thorough understanding of pharmacokinetics is therefore essential when encountering drug adverse effects. We present a case of recurrent severe hypocalcaemia secondary to denosumab administration in a patient with chronic kidney disease. This case report highlights the importance of close monitoring of calcium levels in patients with established risk factors for hypocalcaemia, as well as in those who have achieved resolution of denosumab-induced hypocalcaemia.
More Related Videos
Related Concept Videos
Skeleton and Calcium Homeostasis
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Remodeling
Synthesis and Functions of Calcitonin
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
Osteoclasts in Bone Remodeling
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...

