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Pseudo-Chédiak-Higashi anomaly
American Journal of Clinical Pathology
|January 1, 1985
Summary
Pseudo-Chediak-Higashi anomaly was observed in a patient with myelodysplastic syndrome. The condition progressed from pancytopenia to myeloblastic leukemia over 72 months.
Area of Science:
- Hematology
- Oncology
- Genetics
Background:
- Myelodysplastic syndromes (MDS) are a group of clonal hematopoietic stem cell disorders.
- Pseudo-Chediak-Higashi (PCH) anomaly is a rare inherited disorder of granule formation in leukocytes.
- The association between PCH anomaly and MDS is not well-established.