Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Fractures: Bone Repair

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pharmacological activities and mechanistic insights of justicidin variants: a multi-target natural lignans.

Fitoterapia·2026

Same author

Organ-Specific Distribution and Morphological Characterization of Microplastics in Tor putitora (Golden Mahseer) from the Upper Ganga Basin, Uttarakhand, India.

Bulletin of environmental contamination and toxicology·2026

Same author

Nano-biosensors for circulating tumor markers: advancing liquid biopsy toward precision cancer diagnostics.

Journal of cancer research and clinical oncology·2026

Same author

Saprolegnia species isolated from rainbow trout: molecular identification, specific PCR and drug sensitivity.

Diseases of aquatic organisms·2026

Same author

Role of gut microbiota in cancer modulation: molecular mechanisms and emerging therapeutic strategies.

Infectious agents and cancer·2026

Same author

Characterization of weathered microplastics in freshwater and fish from the Central Himalayas.

Environmental monitoring and assessment·2026

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial

Published on: September 29, 2015

Single/ Multiple Dose Percutaneously Injected LR-PRP Enhances Union Rate in Fracture Delayed Unions: A Prospective

Kishor Kunal¹, Nitesh Gahlot¹, Neeraj Choudhary¹

¹Department of Orthopedics, AIIMS, Jodhpur, Rajasthan 342005 India.

Indian Journal of Orthopaedics

|December 12, 2024

Summary

Leucocyte-rich Platelet-Rich Plasma (LR-PRP) injections effectively promote bone healing in adults with delayed unions. This treatment catalyzed union in 90.3% of patients, offering a viable alternative for fracture recovery.

Keywords:

Delayed union Diaphyseal fracture Fracture healing LR-PRP Metaphyseal fracture Non-surgical treatment PRP

More Related Videos

Effects of Allogeneic Platelet-Rich Plasma PRP on the Healing Process of Sectioned Achilles Tendons of Rats: A Methodological Description

Effects of Allogeneic Platelet-Rich Plasma PRP on the Healing Process of Sectioned Achilles Tendons of Rats: A Methodological Description

Published on: March 19, 2018

Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis

Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis

Published on: January 4, 2019

Related Experiment Videos

Last Updated: Jun 27, 2026

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial

Published on: September 29, 2015

Effects of Allogeneic Platelet-Rich Plasma PRP on the Healing Process of Sectioned Achilles Tendons of Rats: A Methodological Description

Effects of Allogeneic Platelet-Rich Plasma PRP on the Healing Process of Sectioned Achilles Tendons of Rats: A Methodological Description

Published on: March 19, 2018

Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis

Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis

Published on: January 4, 2019

Area of Science:

Orthopedics
Regenerative Medicine
Biomaterials

Background:

Bone healing typically takes 3-12 weeks, varying by fracture location.
Platelet-Rich Plasma (PRP) utilizes growth factors to accelerate natural healing.
PRP has been explored for treating delayed bone unions.

Purpose of the Study:

To evaluate the efficacy of Leucocyte-rich PRP (LR-PRP) in promoting union of delayed fractures.
To determine the effectiveness of percutaneously administered LR-PRP in adult patients.

Main Methods:

Included patients over 18 years with documented delayed union.
Administered LR-PRP injections, with repeat doses based on radiographic assessment.
Followed up patients monthly after each injection.

Main Results:

Achieved union in 28 out of 31 patients (90.3%).
Most patients (71.4%) required only one LR-PRP injection.
No significant correlation found between the number of injections and healing time.

Conclusions:

Percutaneously administered LR-PRP is an effective treatment for delayed bone union.
LR-PRP serves as a beneficial alternative to accelerate fracture healing.
Treatment efficacy is independent of the injury site.