Related Experiment Video

Updated: Jun 5, 2025

A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies
08:51

A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies

Published on: March 8, 2014

16.6K

The significance of RB1 in multiple myeloma

Yiwen Wang1, Rui Yang1, Rui Liu1

  • 1Department of Hematology, The Second Affiliated Hospital of Xi'an JiaoTong University, Xi'an, Shaanxi, China.

Frontiers in Immunology
|December 12, 2024
PubMed

Insights

Retinoblastoma gene (RB1) loss is common in multiple myeloma (MM) and drives disease progression by affecting cell cycle control. Targeting RB1 presents a promising new therapeutic strategy for MM patients.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Multiple myeloma (MM) treatment has advanced, but its genetic underpinnings require further elucidation.
  • Genetic alterations, including RAS mutations, TP53, RB1 deletions, and 1q21 amplification, are critical in MM pathogenesis.
  • The R2-ISS system highlights the prognostic impact of genetic aberrations in MM.

Purpose of the Study:

  • To review the role of the retinoblastoma gene (RB1) in multiple myeloma.
  • To explore the therapeutic potential of targeting RB1 in MM.

Main Methods:

  • Literature review summarizing genetic alterations in MM.
  • Analysis of RB1's function as a tumor suppressor and its role in cell cycle regulation.
  • Examination of RB1's impact on MM progression and IL-6 secretion.

Main Results:

  • RB1 deletion is a frequent event in MM, contributing to uncontrolled cell proliferation.
  • RB1 loss influences interleukin-6 secretion and overall MM progression.
  • The retinoblastoma protein (pRB) is crucial for regulating cell cycle progression.

Conclusions:

  • RB1 plays a significant role in the development and progression of multiple myeloma.
  • Targeting RB1 offers a potential therapeutic avenue for managing MM.
Keywords:
CDK4/6 inhibitorsRB1gene mutationmultiple myelomapRB

More Related Videos

Inducible and Reversible Dominant-negative DN Protein Inhibition08:35

Inducible and Reversible Dominant-negative DN Protein Inhibition

Published on: January 7, 2019

8.3K
Reconstruct Human Retinoblastoma In Vitro06:52

Reconstruct Human Retinoblastoma In Vitro

Published on: October 11, 2022

1.3K

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.1K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.4K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
35.2K
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
6.2K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.4K
Small GTPases - Ras and Rho01:24

Small GTPases - Ras and Rho

Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
3.9K