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Related Experiment Videos

Evaluation of the S-Plus IV.

K Mayer, B Chin, A Baisley

    American Journal of Clinical Pathology
    |January 1, 1985
    PubMed
    Summary

    The Coulter Counter Model S-Plus IV hematology analyzer demonstrates high accuracy for most blood parameters, significantly improving upon previous models by virtually eliminating aberrant platelet counts. This hematology analyzer is reliable for clinical diagnostics.

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    Area of Science:

    • Hematology
    • Clinical Diagnostics
    • Medical Device Evaluation

    Background:

    • Hematology analyzers are crucial for accurate blood cell counts.
    • Previous generations of the Coulter Counter S-Plus had occasional issues with platelet parameter accuracy.
    • Continuous improvement in hematology analyzer technology is essential for reliable patient diagnosis.

    Purpose of the Study:

    • To evaluate the performance and accuracy of the Coulter Counter Model S-Plus IV hematology analyzer.
    • To specifically assess the reliability of the platelet count parameter.
    • To compare the analyzer's results with manual reference methods for normal and clinical specimens.

    Main Methods:

    • Performance characteristics including precision, linearity, and carryover were assessed.
    • 222 patient samples were analyzed on the Model S-Plus IV and compared to routine laboratory results.
    • 99 normal samples were analyzed and compared against manual reference methods.

    Main Results:

    • High coefficients of correlation (≥0.99) were observed for white blood cell count (WBC), red blood cell count (RBC), hemoglobin (Hgb), and platelets (Plt) against routine lab results.
    • Correlation coefficients for WBC, RBC, and Hgb against manual methods were high (≥0.98).
    • The Model S-Plus IV virtually eliminated the aberrant platelet counts seen in earlier models, with 93% of flagged platelet results being accurate.

    Conclusions:

    • The Coulter Counter Model S-Plus IV exhibits excellent accuracy and reliability for analyzing various hematological parameters, including platelets.
    • The analyzer represents a significant advancement over previous models, particularly in addressing platelet count inaccuracies.
    • While most flagged platelet counts were accurate, manual slide review introduced laboratory inefficiencies.

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