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Associations of the Charlson comorbidity index with depression and mortality among the U.S. adults

Ying-Zhao Wang1, Chun Xue2, Chao Ma3

  • 1Department of Neurology, Qianwei Hospital of Jilin Province, Changchun, China.

Frontiers in Public Health
|December 12, 2024
PubMed

Insights

Chronic comorbidities, measured by the Charlson Comorbidity Index (CCI), increase depression risk. High CCI and depression significantly elevate mortality risk, highlighting the need for targeted clinical care.

Area of Science:

  • Epidemiology
  • Clinical Medicine
  • Public Health

Background:

  • Chronic comorbidities are linked to increased risks of depression and mortality.
  • The Charlson Comorbidity Index (CCI) is a widely used measure of disease burden.
  • Understanding the interplay between comorbidities, depression, and mortality is crucial for patient outcomes.

Purpose of the Study:

  • To investigate the association between the Charlson Comorbidity Index (CCI) and depression.
  • To examine the combined impact of CCI and depression on all-cause mortality.
  • To identify patient groups at highest risk for adverse outcomes.

Main Methods:

  • Utilized data from the National Health and Nutrition Examination Survey (NHANES) (2007-2018) with 23,927 adult participants.
  • Categorized CCI into three groups: CCI=0 (T1), CCI=1 (T2), and CCI≥2 (T3).
  • Employed multivariable logistic regression and Cox proportional hazards models to analyze relationships.

Main Results:

  • A significant positive association was found between CCI and depression (OR=1.25).
  • Higher CCI was linked to increased mortality in individuals with depression (HR=1.14).
  • Patients with CCI≥2 and depression faced a substantially elevated mortality risk (HR=2.01) compared to those with CCI=0 and no depression.

Conclusions:

  • The Charlson Comorbidity Index (CCI) is positively correlated with depression risk.
  • Increased all-cause mortality is associated with higher CCI, particularly in patients with depression.
  • Prioritizing clinical care for individuals with high CCI (≥2) and depression is essential to reduce mortality.
Abstract

Keywords:
CCINHANESchronic diseasesdepressionmortality

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