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Prognostic significance of elevated expression levels of protein phosphatase 1 regulatory subunit 3G in thyroid carcinoma

  • 0Department of Cardiology, Zibo Central Hospital, Zibo, Shandong 255036, P.R. China.
Oncology Letters +

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December 12, 2024

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December 12, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Protein phosphatase 1 regulatory subunit 3G (PPP1R3G) is elevated in thyroid carcinoma (THCA), correlating with poorer prognosis. This gene shows potential as a biomarker for early THCA detection and predicting patient survival outcomes.

Area Of Science

  • Oncology
  • Molecular Biology
  • Genetics

Background

  • Poorly differentiated thyroid carcinoma (THCA) presents a challenging prognosis due to aggressive behavior and metastasis.
  • Identifying reliable biomarkers for early detection and prognosis prediction in THCA is crucial for improving patient outcomes.

Purpose Of The Study

  • To investigate the role of protein phosphatase 1 regulatory subunit 3G (PPP1R3G) as a potential molecular biomarker in THCA.
  • To assess the prognostic significance and underlying mechanisms of PPP1R3G in THCA progression.

Main Methods

  • Utilized The Cancer Genome Atlas (TCGA) database for gene expression and survival analysis in THCA.
  • Employed immunohistochemistry for protein expression validation.
  • Performed Cox regression models for prognostic significance analysis.
  • Conducted functional enrichment analysis and immune cell infiltration assessment.

Main Results

  • PPP1R3G mRNA and protein levels were significantly higher in THCA tissues compared to normal thyroid tissues.
  • Increased PPP1R3G expression was associated with clinical factors including sex, histology, pathological stage, and extrathyroidal extension.
  • PPP1R3G demonstrated independent prognostic value for predicting overall survival (OS) in THCA patients.
  • Functional analysis suggested PPP1R3G involvement in keratinization and keratinocyte differentiation.
  • PPP1R3G expression correlated with immune cell infiltration in the thyroid tumor microenvironment.

Conclusions

  • PPP1R3G serves as a potential prognostic indicator for THCA patients.
  • PPP1R3G may represent a promising therapeutic target for THCA interventions.
  • Further research into PPP1R3G's role could enhance early diagnosis and treatment strategies for THCA.

Keywords:

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