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EvoraPlus Oral Probiotic Tablet: New paradigm for Caries Prevention in Children
Akanksha Mishra1, Siddharth Saurabh2
1Department of Pediatric and Preventive Dentistry, Bhabha College of Dental Sciences, Bhabha University, Bhopal, Madhya Pradesh, India.
Insights
Oral probiotics like Evora Plus significantly reduced harmful bacteria and increased salivary pH in children over 30 days. This suggests Evora Plus may be a beneficial tool for preventing cavities and improving children's oral health.
Area of Science:
- Microbiology
- Pediatric Dentistry
- Oral Health
Background:
- Probiotics, defined by the WHO, are live microorganisms conferring health benefits.
- Oral probiotics may reduce cariogenic bacteria, promoting better oral health in children.
- Evora Plus is a novel oral probiotic tablet containing *Streptococcus oralis* KJ3sm, *Streptococcus uberis* KJ2sm, and *Streptococcus rattus* JH145.
Purpose of the Study:
- To evaluate the efficacy of the Evora Plus oral probiotic tablet.
- To compare salivary total bacterial count, salivary pH, and salivary *Streptococcus mutans* (*S. mutans*) count before and after 30 days of consumption.
- To assess the impact of Evora Plus on the oral microbiome of children.
Main Methods:
- A 30-day clinical study involving 40 caries-free schoolchildren aged 12-14 years.
- Participants were divided into control and test groups, with the test group consuming Evora Plus.
- Salivary samples were analyzed for total bacterial count, *S. mutans* count, and pH levels using standard microbiological and digital pH meter methods.
Main Results:
- A significant reduction in salivary total bacterial count was observed in the Evora Plus group.
- Salivary *S. mutans* counts significantly decreased after 30 days of Evora Plus consumption.
- A significant increase in salivary pH was recorded in children using the Evora Plus oral probiotic tablet.
Conclusions:
- Oral probiotic formulations, such as Evora Plus, can effectively reduce cariogenic microorganisms.
- The Evora Plus oral probiotic tablet shows promise as a preventative measure against enamel demineralization.
- Evora Plus may represent a new paradigm for caries prevention in pediatric populations.
Background:
According to the World Health Organization, probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit to the host. The use of oral probiotics in children to improve oral health may lead to nonpathogenic bacteria replacing cariogenic bacteria. The Evora Plus oral probiotics tablet is the first such oral probiotics tablet containing a proprietary blend of three select species of naturally occurring oral bacteria, each with a specific function for maintaining a healthy oral environment. These strains include Streptococcus oralis KJ3sm, Streptococcus uberis KJ2sm, and Streptococcus rattus JH145.
Aim:
To compare the levels of salivary total bacterial count, salivary pH levels, and salivary S. mutans count before and after consumption of the Evora Plus oral probiotic tablet.
Materials And Methods:
Around 40 caries-free schoolchildren from Daksh International School, Gadarwara, Madhya Pradesh, India, aged 12-14 years, were selected and divided equally into two groups-group A, in which total salivary bacterial count and pH were evaluated, and group B, in which salivary S. mutans count and pH were evaluated. These groups were further subdivided into group A1 and group B1, which served as the control groups not receiving the Evora Plus oral probiotic tablet, and group A2 and group B2, which were the test groups consuming the Evora Plus oral probiotic tablet for 30 days. Assessment of salivary samples for total bacterial count was done at baseline and after 30 days for groups A1 and B1. Salivary pH estimation was done at baseline and after 30 days for the entire group, and salivary S. mutans count was done at baseline and after 30 days for groups A2 and B2. Salivary pH level was checked using a digital pH meter; nutrient agar was used for salivary total bacterial count, while Mitis salivarius bacitracin agar was used for salivary S. mutans count. The number of colonies was counted and subjected to statistical analysis using unpaired and paired Student's t-test.
Results:
The study showed a significant reduction in salivary total bacterial count and salivary S. mutans counts, as well as a significant increase in salivary pH after 30 days in the Evora Plus oral probiotic group compared with the group not receiving the Evora Plus oral probiotic tablet.
Conclusion:
Cariogenic microorganisms could be reduced by an oral probiotic formulation. Thus, the use of the Evora Plus oral probiotic tablet could be recommended for the prevention of enamel demineralization.
How To Cite This Article:
Mishra A, Saurabh S. EvoraPlus Oral Probiotic Tablet: New paradigm for Caries Prevention in Children. Int J Clin Pediatr Dent 2024;17(9):1044-1048.
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