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Lipid-lowering agent preferences among patients with hypercholesterolemia: a focus group study
Hei Hang Edmund Yiu1, Kehui Deng2, Lydia Wy Fung1,3
1Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Journal of Pharmaceutical Policy and Practice
|December 12, 2024
Summary
Understanding patient preferences for lipid-lowering agents is crucial for improving adherence. Key barriers include knowledge gaps and pill burden, while effectiveness and cost influence choices.
Area of Science:
- Cardiology
- Pharmacoeconomics
- Patient Adherence Research
Background:
- Non-adherence to lipid-lowering agents significantly impacts patient outcomes and treatment efficacy.
- Limited understanding exists regarding patient preferences for lipid-lowering medication characteristics.
- Hypercholesterolemia management requires addressing patient-specific factors influencing treatment adherence.
Purpose of the Study:
- To qualitatively identify barriers to lipid-lowering medication adherence.
- To determine factors influencing lipid-lowering agent selection in hypercholesterolemia patients.
- To inform the design of a comprehensive medication preference study.
Main Methods:
- Focus group interviews with Cantonese-speaking hypercholesterolemia patients in Hong Kong.
- Thematic analysis of interview transcripts to identify key themes.
- Discrete Choice Experiment (DCE) method used for medication preference tasks.
Main Results:
- Identified adherence barriers: lack of knowledge, high pill burden, poor communication, limited involvement in decisions, side effects, and forgetfulness.
- Key factors influencing medication choice: treatment regimen, effectiveness, side effects, physician opinion, drug interactions, and out-of-pocket costs.
- Medication preference tasks effectively captured patient trade-offs.
Conclusions:
- Patient perspectives on adherence barriers and medication choice factors are critical for effective treatment selection.
- Incorporating patient preferences can enhance medication adherence.
- A large-scale DCE study is planned to quantify attribute importance for lipid-lowering agents.
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