Granulomatosis with polyangiitis mimicking multisystem pyoderma gangrenosum: A case report

Area of Science:

• Rheumatology
• Nephrology
• Dermatology

Background:

• Granulomatosis with polyangiitis (GPA) is a rare small-medium vessel vasculitis.
• GPA diagnosis can be challenging due to varied clinical presentations.

Observation:

• A case presented mimicking multisystem pyoderma gangrenosum.
• The patient exhibited cutaneous ulceration and renal sparing.
• Antineutrophil cytoplasmic antibody (ANCA) testing was negative.

Findings:

• GPA diagnosis should be considered despite ANCA negativity.
• Pyoderma gangrenosum-like ulcers can be a manifestation of GPA.
• Multisystem involvement is key in suspecting GPA.

Implications:

• This case emphasizes the need for high clinical suspicion for GPA.
• Diagnostic challenges in GPA require a broad differential diagnosis.
• Early recognition of GPA is crucial for timely treatment and improved outcomes.