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Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

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[Experimental studies of biodegradable ureteral stent prototype].

N G Sedush¹, E A Anokhin¹, S N Chvalun¹

¹Enikolopov Institute of Synthetic Polymeric Materials, Moscow, Russia.

|December 12, 2024

Summary

A new biodegradable ureteral stent made from poly(L-lactide-co-ε-caprolactone) shows promise for preventing complications from forgotten stents. This degradable stent material maintains strength for at least two weeks and is not toxic to cells.

Keywords:

biodegradable polymers hydrolytic degradation mechanical testing molecular weight ureteral stent

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Area of Science:

Biomaterials Science
Urology
Polymer Chemistry

Context:

Forgotten ureteral stents lead to significant complications in urology.
Current ureteral stents often require a secondary procedure for removal.
There is a clinical need for self-removing, degradable ureteral devices.

Purpose:

To develop and characterize a novel biodegradable ureteral stent.
To evaluate the mechanical properties and degradation profile of the stent material.
To assess the biocompatibility of the new stent material.

Summary:

A prototype biodegradable ureteral stent was synthesized using poly(L-lactide-co-ε-caprolactone).
The material demonstrated adequate strength and elasticity for stent applications.
Degradation analysis in artificial urine showed sustained strength for over two weeks, with no observed cellular toxicity.

Impact:

This novel biomaterial offers a potential solution to the 'forgotten stent' problem.
The developed stent material is suitable for further development and in vivo testing.
Successful clinical translation could reduce patient morbidity and healthcare costs associated with ureteral stent management.