Perioperative outcomes in elderly patients undergoing pancreatoduodenectomy: a propensity-matched analysis

To investigate perioperative outcomes of pancreatoduodenectomy in elderly patients.

Data for 977 patients who underwent pancreatoduodenectomy from January 2018 to January 2023 were retrospectively analysed. Patients aged 75 years or older (n = 81) were matched with patients younger than 75 years (n = 896) using nearest neighbour propensity scores matching in a 1:1 ratio.

After matching, there were no significant differences in perioperative characteristics between the old group (n = 80) and the young group (n = 80). Regarding perioperative outcomes, we observed a higher incidence of postpancreatectomy haemorrhage (13.8% vs. 3.8%; P = 0.025) and pulmonary infection (26.3% vs. 8.8%; P = 0.004) in the old group. The major morbidity (Clavien-Dindo ≥3), cardiovascular complications and length of stay were higher in the old group before matching, however, no difference was observed between the matched cohorts (P > 0.05). The multivariate analysis revealed ASA score ≥3 (OR = 3.672, 95% CI 1.367-9.863; P = 0.010) and longer operative time (OR = 1.006, 95% CI 1.000-1.011; P = 0.039) were independently identified as risk factors for major morbidity. Moreover, the subgroup analysis demonstrated that laparoscopic surgery significantly mitigated the incidence of major morbidity in elderly patients.

With careful patient selection and perioperative management, elderly patients may achieve comparable short-term outcomes to those of their younger counterparts.