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Association between Visceral Fat Content and Obesity-Related Indicators with Cognitive Impairment after Intracerebral
Yuchen Wang1, Xutong Zhu1, Xin Zhang2
1The First Clinical Medical College of Zhejiang Chinese Medical University, 310053 Hangzhou, Zhejiang, China.
Insights
Waist-to-height ratio (WHtR) is inversely associated with cognitive impairment after intracerebral hemorrhage (ICH). Lower adiponectin levels were observed in overweight ICH patients with cognitive impairment.
Area of Science:
- Neurology
- Metabolic Syndrome
- Public Health
Background:
- Intracerebral hemorrhage (ICH) is a significant cause of death and disability, frequently resulting in long-term cognitive deficits.
- Investigating factors contributing to post-ICH cognitive impairment is crucial for improving patient outcomes and quality of life.
Purpose of the Study:
- To examine the relationship between visceral fat indicators (BMI, WC, WHtR), adiponectin levels, and cognitive dysfunction following ICH.
- To identify potential biomarkers for predicting cognitive impairment in ICH survivors.
Main Methods:
- 388 ICH patients underwent measurements of BMI, waist circumference (WC), and waist-to-height ratio (WHtR).
- Visceral fat content was estimated from CT scans, and adiponectin levels were measured using ELISA.
- Cognitive function was assessed using the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (miniMoCA).
Main Results:
- Lower BMI, WC, and WHtR were observed in the cognitive impairment group (p < 0.01).
- Overweight patients had better cognitive scores (MMSE, miniMoCA) than normal-weight and obese patients, respectively.
- Multivariate analysis revealed WHtR as an independent predictor inversely associated with post-ICH cognitive impairment (OR = 0.233, p = 0.016).
Conclusions:
- Waist-to-height ratio (WHtR) is independently and inversely associated with cognitive impairment risk after ICH.
- Adiponectin levels did not show a significant overall correlation with cognitive impairment, but were lower in overweight ICH patients with cognitive impairment.
Background:
Intracerebral hemorrhage (ICH) is a major cause of morbidity and mortality, often leading to long-term cognitive impairment that significantly diminishes the quality of life. This study investigated the relationship between visceral fat content, obesity-related indicators, and cognitive dysfunction following ICH.
Methods:
A total of 388 subjects with ICH who were admitted to the Neurosurgery Department of the Hospital and met the inclusion and exclusion criteria were included in this study. Obesity-related indicators, including body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR), were measured. L3 level images were obtained by abdominal computerized tomography (CT). The visceral fat content was estimated using IMAGE J software, and adiponectin levels were assessed via enzyme-linked immunosorbent assay (ELISA). The Mini-Mental State Examination (MMSE) was used to evaluate the cognitive level of patients within 2 weeks of onset, and the shortened version of the Montreal Cognitive Assessment (miniMoCA) was used to evaluate the cognitive level of patients 6 months after ICH. Univariate and multivariate analyses were used to analyze the correlations of BMI, WC, WHtR, abdominal fat, and adiponectin with cognitive impairment after ICH.
Results:
BMI, WC, and WHtR were lower in the cognitive impairment group (p < 0.01). Overweight patients exhibited higher MMSE scores than normal-weight patients (p < 0.05) and higher miniMoCA scores than obese patients (p = 0.014). Abdominal obesity, assessed by WC and WHtR, was associated with higher MMSE scores (p = 0.022 and 0.003, respectively). Multivariate analysis indicated that WHtR was associated with cognitive impairment risk post-ICH (odds ratio (OR) = 0.233, 95% confidence interval (CI) (0.071, 0.762); p = 0.016). Although no overall association was found between adiponectin levels and cognitive impairment, subgroup analysis revealed lower adiponectin levels in overweight patients with cognitive impairment (p = 0.040).
Conclusion:
WHtR is independently and inversely associated with cognitive impairment after ICH. There is no significant correlation between adiponectin with cognitive impairment after ICH, while subgroup analysis indicates that adiponectin levels are lower in overweight patients with cognitive impairment.
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