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Related Concept Videos

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

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Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
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Neuromodulation techniques for modulating cognitive function: Enhancing stimulation precision and intervention

Hanwen Cao1,2, Li Shang1,2, Deheng Hu1,2

  • 1State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China.

Neural Regeneration Research
|December 12, 2024
PubMed
Summary
This summary is machine-generated.

Neuromodulation techniques, both invasive and non-invasive, offer significant potential for cognitive function enhancement. Non-invasive methods are particularly promising for broader applications due to their safety and accessibility.

Keywords:
acupuncture pointsattentionbraincognitionefficiencyelectrical stimulationmicroelectrodesmovement disordersnervous systemperception

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Cognitive Science

Background:

  • Neuromodulation techniques are crucial for understanding and intervening in cognitive functions across various scientific fields.
  • Cognitive regulation encompasses perception, memory, attention, and spatial cognition, with applications in aerospace, medicine, and brain research.

Purpose of the Study:

  • To review recent advancements and challenges in invasive and non-invasive neuromodulation techniques for cognitive function modulation.
  • To assess the suitability of different neuromodulation methods for the general population.

Main Methods:

  • Systematic review of recent publications on neuromodulation techniques from the Web of Science.
  • Analysis of invasive (deep brain stimulation, vagus nerve stimulation, microelectrode arrays) and non-invasive (TMS, tDCS, tACS, transcutaneous electrical acupoint stimulation, time interference stimulation) methods.

Main Results:

  • Invasive methods, while effective for disease research, pose higher trauma risks and are less explored for general cognitive enhancement.
  • Non-invasive techniques, especially newer transcranial and acupoint stimulation methods, are safer and more applicable for widespread cognitive regulation.
  • Transcutaneous acupoint electrical stimulation and time interference stimulation show promise for deep brain target activation.

Conclusions:

  • Non-invasive neuromodulation techniques are more appropriate for regulating cognitive functions in the general population.
  • Combining neuromodulation with neural detection methods can improve efficacy and accuracy.
  • Closed-loop feedback neuromodulation represents a significant future research direction.