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Updated: Jun 5, 2025

Porous Silicon Microparticles for Delivery of siRNA Therapeutics
Published on: January 15, 2015
Bioengineered Nanomaterials for siRNA Therapy of Chemoresistant Cancers
Mehdi Sanati1, Christian G Figueroa-Espada2, Emily L Han2
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Birjand University of Medical Sciences, Birjand 97178, Iran.
Abstract:
Chemoresistance remains a long-standing challenge after cancer treatment. Over the last two decades, RNA interference (RNAi) has emerged as a gene therapy modality to sensitize cancer cells to chemotherapy. However, the use of RNAi, specifically small-interfering RNA (siRNA), is hindered by biological barriers that limit its intracellular delivery. Nanoparticles can overcome these barriers by protecting siRNA in physiological environments and facilitating its delivery to cancer cells. In this review, we discuss the development of nanomaterials for siRNA delivery in cancer therapy, current challenges, and future perspectives for their implementation to overcome cancer chemoresistance.
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