Investigation of clinical and subclinical renal damage in Psoriasis

Psoriasis is a common systemic inflammatory disease and the literature has reported varying results regarding the renal involvement of psoriasis. Although many studies have investigated the presence of chronic renal damage in patients with psoriasis, there are few studies demonstrating subclinical renal damage. The aim of this study was to prospectively evaluate the presence of clinical and subclinical renal damage in patients with psoriasis vulgaris (PV). The study prospectively enrolled 44 PV patients and 44 healthy controls. Serum urea (BUN), creatinine levels, glomerular filtration rate (GFR), complete urinalysis, urine microscopy and subclinical renal damage markers albuminuria, proteinuria, urinary kidney injury molecule-1 (uKIM-1)/creatinine, urinary neutrophil gelatinase-associated lipocalin (uNGAL)/creatinine and urinary podocalyxin/creatinine levels were measured and compared in both groups.Proteinuria levels were found to be statistically significantly higher in patients with PV (p = 0.021). A positive correlation was observed between proteinuria levels and uKIM-1/creatinine, uNGAL/creatinine and albuminuria levels in the patient group (p = 0.013, r = 0.373; p = 0.017, r = 0.358; p = 0.017, r = 0.358, respectively). This study concluded that PV does not cause clinical kidney injury. Increased proteinuria in PV patients supports the presence of subclinical renal damage. Regular monitoring of proteinuria and uKIM-1/creatinine, uNGAL/creatinine and albuminuria levels, which are positively correlated with proteinuria, may allow early detection of renal damage in PV patients.