Working memory deficit in patients with focal epilepsy is associated with higher interictal theta connectivity

Interictal cognitive disturbances are frequent in patients with focal epilepsies and the links with alteration of resting state brain oscillations are not well known. Changes in theta oscillations, may contribute to cognitive impairment. This study aimed to investigate whether changes in theta activity are related to cognitive disturbances.

Retrospective data of 23 patients with temporal/frontal lobe epilepsy were included. Theta connectivity, power and interictal spikes rate from five-minute interictal resting state stereoelectroencephalography datasets were computed. Cognitive performances were assessed by Wechsler Intelligence Scale (WAIS-IV) and Weschler Memory Scale (WMS-III). Linear regression was performed to evaluate effect of interictal activity and seizure related parameters on cognitive scores.

WAIS-IV working memory score in patients with epilepsy showed negative correlation with frontotemporal theta connectivity (F(1,17) = 5,239, p = 0,036, R² = 0,200, β = -0,497). Moreover, theta connectivity was correlated with mesial temporal spike rate and theta power (F(2,17) = 10,967, p = 0,001, adj.R² = 0,540).

Patients with focal epilepsy often encounter compromised cognitive functions, particularly notable in the domain of working memory. This impairment might be attributed to physiological mechanisms involving increased theta connectivity within the frontotemporal regions and interictal spiking.

Our study highlights the relation between theta connectivity and working memory impairments in patients with focal epilepsy.