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Relief of chronic arterial obstruction using intravenous brinase. A control study
Insights
Brinase, a thrombolytic enzyme, effectively recanalized arterial segments in patients with chronic arterial obstruction. This treatment significantly improved blood flow compared to placebo, offering a potential therapy for this condition.
Area of Science:
- Vascular Medicine
- Pharmacology
- Biochemistry
Background:
- Chronic arterial obstruction poses significant health risks.
- Limited effective therapeutic options exist for arterial obstruction.
- Thrombolytic enzymes are being explored for vascular recanalization.
Purpose of the Study:
- To evaluate the efficacy of the thrombolytic enzyme brinase in treating chronic arterial obstruction.
- To compare brinase treatment with a placebo in patients with arterial disease.
Main Methods:
- A therapeutic trial involving patients with chronic arterial obstruction.
- Administration of six intravenous infusions of either brinase or saline placebo over two weeks.
- Diagnosis and monitoring using ankle blood pressure, Doppler ultrasound scanning, and arteriography.
Main Results:
- Brinase treatment led to recanalization in 17 out of 27 obstructed arterial segments.
- The number of patent arterial segments increased from 11 to 27 following brinase infusion.
- No significant improvement was observed in the placebo group, with statistically significant differences favoring brinase.
Conclusions:
- Brinase demonstrates significant efficacy in recanalizing obstructed arterial segments in patients with chronic arterial obstruction.
- The study suggests brinase as a promising therapeutic agent for improving vascular patency.
- Further research may explore long-term outcomes and optimal dosing of brinase.
Abstract:
A therapeutic trial using placebo or the thrombolytic enzyme brinase was carried out in a group of patients with chronic arterial obstruction. The patients were observed for 3 months before receiving six intravenous infusions of either saline or brinase over a period of 2 weeks. Ankle blood pressure, Doppler ultrasound scanning, and arteriography were used to establish diagnosis in the patients. No changes were observed during the 3-month pre-observation period. After six brinase infusions, recanalization of 17 out of 27 obstructed arterial segments was recorded and the number of patent segments increased from 11 to 27. No improvement was observed in the placebo-treated patients. The differences between brinase and placebo treatment was statistically significant.