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Advanced dressings based on novel biological targets for diabetic wound healing: A review
Lantian Huang1, Hangbo Chen1, Jing Nie1
1Department of Pharmacy, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, 310052, China; Research Center for Clinical Pharmacy, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Abstract:
The diabetic wound is one of the most common complications of diabetes in clinic. The existing diabetic wound dressings all have bottlenecks in decreasing inflammation, stopping peripheral neuropathy, relieving local ischemia and hypoxia in diabetic wounds. These challenges are intricately linked to the roles of various growth factors, as well as matrix metalloproteinases. Thus, a comprehensive understanding of growth factors-particularly their dynamic interactions with the extracellular matrix (ECM) and cellular components-is essential. Cells and proteins that influence the synthesis of growth factors and matrix metalloproteinases emerge as potential therapeutic targets for diabetic wound management. This review discusses the latest advancements in the pathophysiology of diabetic wound healing, highlights novel biological targets, and evaluates new wound dressing strategies designed for the treatment of diabetic wounds.
Insights
Diabetic wound healing faces challenges due to inflammation and poor blood flow. Understanding growth factors and matrix metalloproteinases offers new therapeutic targets for advanced wound dressings.
Area of Science:
- Biomedical Engineering
- Wound Healing Research
- Diabetic Complications
Background:
- Diabetic wounds are a common and challenging clinical complication.
- Current diabetic wound dressings struggle to address inflammation, neuropathy, ischemia, and hypoxia.
- Growth factors and matrix metalloproteinases play critical roles in diabetic wound pathophysiology.
Purpose of the Study:
- To review recent advancements in diabetic wound healing pathophysiology.
- To identify novel biological targets for therapeutic intervention.
- To evaluate innovative wound dressing strategies for diabetic wounds.
Main Methods:
- Literature review of pathophysiology and therapeutic targets.
- Analysis of growth factor and matrix metalloproteinase roles.
- Evaluation of current and emerging wound dressing technologies.
Main Results:
- Diabetic wound healing is complex, involving intricate interactions between cells, extracellular matrix (ECM), growth factors, and matrix metalloproteinases.
- Specific cellular components and proteins influencing growth factor and matrix metalloproteinase synthesis are key therapeutic targets.
- Novel wound dressing strategies aim to overcome existing limitations by addressing multiple aspects of the pathophysiology.
Conclusions:
- A comprehensive understanding of growth factor dynamics within the ECM is crucial for effective diabetic wound management.
- Targeting cellular and protein synthesis pathways offers promising therapeutic avenues.
- Advanced wound dressings incorporating these insights are essential for improving treatment outcomes in diabetic patients.
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