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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

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"3D channel maze" to control drug release from multiple unit tablets.

Huipeng Xu¹, Liu Zhang², Longwei Fang³

¹Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Journal of Controlled Release : Official Journal of the Controlled Release Society

|December 12, 2024

Summary

This study reveals how the internal 3D structure of multiple unit pellet systems (MUPS) controls drug release. A 3D maze network, visualized using synchrotron radiation X-ray micro-computed tomography (SR-μCT), dictates theophylline release kinetics.

Keywords:

Channel maze Controlled release Synchrotron radiation Theophylline Three dimension

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Area of Science:

Pharmaceutical Sciences
Materials Science
Biomedical Engineering

Background:

Drug release from advanced delivery systems is complex, with dosage form structure playing a critical, yet often unknown, role.
Understanding the dynamic internal architecture of dosage forms is crucial for optimizing drug delivery and therapeutic outcomes.

Purpose of the Study:

To investigate the role of internal 3D structure in drug release from multiple unit pellet systems (MUPS).
To visualize and quantify the structural evolution of MUPS during drug release using advanced imaging techniques.

Main Methods:

Utilized synchrotron radiation X-ray micro-computed tomography (SR-μCT) for high-resolution 3D imaging of MUPS.
Applied pore network analysis to extract drug release pathways and construct a 3D maze model.
Analyzed theophylline release kinetics in relation to the evolving internal structure.

Main Results:

Visualized the hierarchical 3D structure of theophylline MUPS, including pellets, cushion layer, and matrix layer.
Identified a 3D channel maze network formed by interconnected pathways within the MUPS.
Demonstrated that this 3D maze architecture significantly influences and controls theophylline release kinetics over time.

Conclusions:

The internal 3D channel maze structure is a key determinant of controlled drug release from MUPS.
SR-μCT and pore network analysis provide powerful tools for understanding drug release mechanisms at a microstructural level.
This study presents a novel approach to control drug release by engineering the 3D channel maze architecture within dosage forms.