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Soluble CTLA-4 - A confounding factor in CTLA-4 based checkpoint immunotherapy in cancer

Parviz Azimnasab-Sorkhabi1, Maryam Soltani-Asl1, Musab Bouhajra2

  • 1Department of Surgery, School of Veterinary Medicine and Animal Sciences, University of Sao Paulo, Sao Paulo, Brazil; Pelotonia Institute for Immuno-Oncology and Division of Medical Oncology, Department of Internal Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.

Immunology Letters
|December 12, 2024
PubMed

Keywords:
CTLA-4CTLA-4 isoformsImmunotherapy(,) CancersCTLA-4

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Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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