Related Experiment Video

Updated: Jun 5, 2025

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
04:23

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

238

Molecular mechanisms and potential interventions during aging-associated sarcopenia

Xiaoqin Luo1, Jin Wang1, Qingqing Ju1

  • 1College of Life Science, Liaoning University, Shenyang 110036, China.

Mechanisms of Ageing and Development
|December 12, 2024
PubMed

Insights

Sarcopenia, muscle loss in aging, lacks clear causes and treatments. Understanding its aging-related mechanisms like inflammation and oxidative stress is key for developing interventions.

Area of Science:

  • Gerontology
  • Muscle physiology
  • Aging research

Background:

  • Sarcopenia is a prevalent condition in the elderly, posing a significant public health concern.
  • Its etiology is complex and not fully understood, involving multiple aging-related processes.
  • Current pharmacological treatments for sarcopenia are limited, necessitating further research.

Purpose of the Study:

  • To provide a comprehensive overview of sarcopenia pathogenesis.
  • To summarize current therapeutic and preventive strategies for sarcopenia.
  • To highlight the need for deeper understanding to enable proactive interventions.

Main Methods:

  • Literature review of aging-related processes implicated in sarcopenia.
  • Analysis of current research on sarcopenia etiology.
  • Synthesis of existing treatment and prevention strategies.

Main Results:

  • Aging processes such as inflammation, oxidative stress, mitochondrial dysfunction, and apoptosis contribute to sarcopenia.
  • The precise causative factors of sarcopenia remain under investigation.
  • Effective pharmacological interventions are currently unavailable.

Conclusions:

  • A deeper understanding of sarcopenia pathogenesis is crucial for developing effective treatments.
  • Targeting aging-related pathways may offer potential therapeutic avenues.
  • Proactive strategies for sarcopenia prevention and management are needed.
Keywords:
EpigeneticMuscle massMyokineOxidative stressSarcopenia

More Related Videos

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

12.5K
Techniques to Induce and Quantify Cellular Senescence06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

33.1K

Related Concept Videos

Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
37
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
10.9K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
3.4K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.7K