[Clinical characteristics of undifferentiated pleomorphic sarcoma from the head and neck]

The medical data of 10 patients with undifferentiated pleomorphic sarcoma (UPS) from the head and neck at Henan Cancer Hospital from January 2013 to January 2023 were retrospectively analyzed. There were 5 males and 5 females, aged (57.6±13.1) years. The lesions were located in the nasal cavity (one case), the paranasal sinuses (two cases), the parotid gland (one case), the nape (one case), the thyroid gland (one case), and the neck (four cases), respectively. Eight patients underwent surgical intervention, all of whom received adjuvant therapies, including post-surgery radiotherapy and chemotherapy. One patient declined treatment due to personal reasons, and another patient lost the opportunity for surgery and received chemotherapy instead. The follow-up period ranged from 1 to 128 months, with a median follow-up time of 31 (11, 101) months. During the follow-up period, there were a total of four deaths: two due to recurrence after surgery, one due to discontinuing treatment, and one due to severe illness that responded poorly to treatment.The remaining 6 patients who received surgery combined with radiotherapy or chemotherapy showed no recurrence. To sum up, UPS of the head and neck is rare, exhibits a high recurrence rate, and has a poor prognosis. Surgical resection combined with radiotherapy is an important treatment modality.