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Related Experiment Videos

H-reflex changes following spinal cord injury.

J W Little, E M Halar

    Archives of Physical Medicine and Rehabilitation
    |January 1, 1985
    PubMed
    Summary

    Central synaptic excitability (CSE) increases after spinal cord injury (SCI), contributing to hyperactive stretch reflexes. This study tracked H-reflex changes in SCI patients over six months, finding significant excitability increases.

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    Area of Science:

    • Neuroscience
    • Physiology
    • Rehabilitation Medicine

    Background:

    • Spasticity involves hyperactive stretch reflexes, potentially due to altered central synaptic excitability (CSE) and muscle spindle sensitivity.
    • Understanding the time course of these changes post-spinal cord injury (SCI) is crucial for developing effective interventions.

    Purpose of the Study:

    • To investigate changes in CSE following traumatic spinal cord injury (SCI).
    • To assess the contribution of CSE to the development of hyperreflexia after SCI.

    Main Methods:

    • Monosynaptic H-reflex of the triceps surae muscles was measured serially for six months post-SCI in six patients.
    • H-reflex excitability was quantified using H/M ratios (maximum H-reflex amplitude divided by maximum M-response amplitude).
    • Comparisons were made between SCI patients and age-matched controls.

    Main Results:

    • SCI patients exhibited significant changes in H/M ratios over time (p < 0.01).
    • A significant increment in H/M ratios was observed three months post-SCI (p < 0.01).
    • H-reflex amplitude increased significantly (p < 0.04) without changes in M-response amplitude, indicating increased neuronal excitability.

    Conclusions:

    • Increased central synaptic excitability (CSE) likely contributes to the hyperreflexia observed after spinal cord injury.
    • The findings suggest a temporal development of altered neuronal excitability in the early post-SCI period.

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