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Updated: Jun 5, 2025

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Remote C(sp3)-H Carboxylation with CO2 via Visible-Light-Catalyzed 1,5-Hydrogen Atom Transfer
Haoran Huang1,2, Xiaoyu Lin1,3,2, Fanyuanhang Yang1
1State Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China.
Abstract:
The direct carboxylation of C(sp3)-H bonds with CO2 represents a challenging but highly attractive strategy in organic synthesis. In this study, we presented a visible-light-catalyzed strategy for carboxylating remote C(sp3)-H bonds with CO2 via aryl radical induced 1,5-hydrogen atom transfer. This transformation involves generating alkyl radicals via 1,5-hydrogen atom transfer from aryl radicals, forming alkyl carbanions as key intermediates, and a subsequent nucleophilic attack with CO2, thereby enabling access to a variety of tertiary and quaternary carboxylic acids in moderate to good yields.
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