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Updated: Jun 5, 2025

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Biomimetic prebiotic synthesis of homochiral peptides via a potential 5'-aa-AMP precursor
Min Zhang1,2, Shoujun Wang1, Li Zhang1
1Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China.
Abstract:
Inspired by biosynthetic peptides, we investigate the chiral recognition properties of adenylate amidate (N-aa-AMP, a potential analog of 5'-aa-AMP) in prebiotic peptide formation. Our findings demonstrate that N-L-aa-AMP preferentially binds to L-aa, facilitating the formation of homochiral peptides, while N-D-aa-AMP shows a preference for D-aa, thereby achieving homochirality in peptide synthesis. Collectively, these results enhance our understanding of the evolutionary origins of homochirality on prebiotic Earth.
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