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Integrative analysis of recurrence related gene signature and STC1 in colorectal cancer proliferation and metastasis

  • 0Department of Gastrointestinal Surgery, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, No. 134 Dongjie, Fuzhou, China.
Journal of Cancer +

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December 13, 2024

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December 13, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

A new 11-gene Recurrence Related Gene Signature (RRGS) accurately predicts colorectal cancer recurrence and patient outcomes. This tool aids in personalizing treatment strategies for better therapeutic response.

Area Of Science

  • Oncology
  • Genomics
  • Molecular Biology

Background

  • Colorectal cancer (CRC) presents significant challenges due to high recurrence and poor prognosis.
  • Effective prediction of treatment response and patient outcomes is crucial for personalized medicine in CRC.

Purpose Of The Study

  • To develop and validate a novel gene signature for predicting recurrence in colorectal cancer.
  • To identify molecular mechanisms underlying CRC recurrence and potential therapeutic targets.

Main Methods

  • Analysis of the GSE17536 cohort to identify differentially expressed genes (DEGs) between recurrent and non-recurrent CRC cases.
  • Development of the Recurrence Related Gene Signature (RRGS) using LASSO regression on identified DEGs.
  • Validation of RRGS performance across multiple datasets and investigation of STC1 function through in vitro and in vivo experiments.

Main Results

  • Identified 79 DEGs (54 upregulated, 25 downregulated) linked to cancer progression and immune processes.
  • Developed an 11-gene RRGS with significant diagnostic and prognostic capabilities for overall survival and disease-free survival.
  • Demonstrated that higher RRGS scores correlate with advanced stages and poorer outcomes, especially post-chemotherapy. STC1 knockdown inhibited proliferation and metastasis.

Conclusions

  • The 11-gene RRGS is a robust tool for predicting colorectal cancer recurrence and guiding personalized treatment.
  • STC1 is identified as a key driver of tumor progression and immune evasion, representing a potential therapeutic target.

Keywords:

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