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Related Experiment Videos

Fingerprint patterns in Alzheimer's disease.

H J Weinreb

    Archives of Neurology
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Patients with Alzheimer-type dementia show distinct fingerprint patterns, specifically more ulnar loops. These findings support links between Alzheimer's disease and Down syndrome.

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    Area of Science:

    • Neuroscience
    • Genetics
    • Dermatoglyphics

    Background:

    • Alzheimer's disease (AD) is a progressive neurodegenerative disorder.
    • Fingerprint patterns (dermatoglyphics) have been studied for potential links to various genetic and neurological conditions.
    • Previous research suggests associations between Alzheimer's disease and Down syndrome.

    Purpose of the Study:

    • To investigate fingerprint dermatoglyphic differences in patients with suspected Alzheimer-type dementia (SDAT).
    • To compare these patterns with a control group and population norms.
    • To explore further the relationship between SDAT and Down syndrome based on dermatoglyphic findings.

    Main Methods:

    • A case-control study comparing fingerprint patterns of 50 SDAT patients with 50 patients with other neurological diseases.

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  • Analysis included frequency counts of different fingerprint patterns (ulnar loops, whorls, arches).
  • Comparison with established population norms for dermatoglyphic patterns.

    • Main Results:

    • Patients with SDAT exhibited a significantly higher frequency of ulnar loops compared to controls.
    • A decrease in whorls and arches was observed in the SDAT group.
    • Having eight or more ulnar loops was significantly more common in SDAT patients (72%) than in controls (26%).
    • Radial loops on specific digits were also more prevalent in SDAT patients.

    Conclusions:

    • Fingerprint dermatoglyphic patterns in SDAT patients differ significantly from control groups.
    • The observed patterns in SDAT are consistent with those found in Down syndrome.
    • These dermatoglyphic findings provide additional support for the known biological links between Alzheimer's disease and Down syndrome.