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Mortality patterns in chronic granulomatous invasive fungal rhinosinusitis: insights from two fatal cases
Hussain J Aljubran1, Omar A Bamalan2, Maria R Alabdulaal3
1College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 43221, Saudi Arabia.
Abstract:
Chronic granulomatous invasive fungal rhinosinusitis (CGIFRS) is a type of invasive fungal rhinosinusitis that is characterized by the presence of pathologic findings of non-caseating granulomas in the paranasal sinuses. This article describes two cases of CGIFRS with fatal outcomes. The first case was for a 36-year-old man who presented with headache, dizziness, and vomiting for 1 month. This patient had received the traditional treatment, although the patient's condition suddenly deteriorated after 1 week of surgery and died due to the disease's complications. Similarly, the second case was for a 31-year-old man who presented with bilateral nasal obstruction and left eye proptosis for 1 year. This patient had a recurrence of CGIFRS after the first presentation, which was complicated by a cerebral abscess after 2 months of surgery. This study, therefore, underscores the severity of CGIFRS as a potentially fatal disease.
Insights
Chronic granulomatous invasive fungal rhinosinusitis (CGIFRS) is a severe fungal infection. This study highlights two fatal cases, emphasizing CGIFRS
Area of Science:
- Otolaryngology
- Mycology
- Pathology
Background:
- Chronic granulomatous invasive fungal rhinosinusitis (CGIFRS) is a distinct subtype of invasive fungal rhinosinusitis.
- CGIFRS is histopathologically defined by non-caseating granulomas in the paranasal sinuses.
Observation:
- This article presents two cases of CGIFRS with fatal outcomes.
- Case 1: A 36-year-old male with CGIFRS experienced rapid deterioration and death post-surgery.
- Case 2: A 31-year-old male with recurrent CGIFRS developed a cerebral abscess post-surgery, leading to a fatal outcome.
Findings:
- CGIFRS can present with severe symptoms including headache, vomiting, nasal obstruction, and proptosis.
- Both presented cases demonstrated aggressive disease progression despite treatment and surgical intervention.
- Complications such as cerebral abscesses can arise, contributing to mortality.
Implications:
- CGIFRS represents a potentially fatal condition requiring urgent and effective management strategies.
- The study underscores the critical need for increased awareness and research into CGIFRS pathogenesis and treatment.
- Early diagnosis and aggressive therapeutic approaches are crucial for improving patient outcomes in CGIFRS.
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