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Clinical, histopathological and immunohistochemical analysis of vulvar squamous cell carcinoma

  • 0Universidade Federal de Ciências da Saúde de Porto Alegre Porto AlegreRS Brazil Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.
Revista Brasileira De Ginecologia E Obstetricia : Revista Da Federacao Brasileira Das Sociedades De Ginecologia E Obstetricia +

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December 13, 2024

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December 13, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

In vulvar squamous cell carcinoma (SCC), p16 expression correlated with less invasion, while abnormal p53 indicated greater invasion. PDL1 expression was linked to more inflammatory cells in these SCC tumors.

Area Of Science

  • Oncology
  • Pathology
  • Immunohistochemistry

Background

  • Vulvar squamous cell carcinoma (SCC) is a significant gynecologic malignancy.
  • Human papilloma virus (HPV) infection is a known risk factor for SCC.
  • Immunohistochemical (IHC) markers like p16, p53, and PDL1 are used to characterize tumors.

Purpose Of The Study

  • To investigate the correlation between p16, p53, and PDL1 expression and the clinical-pathological features of vulvar SCC.
  • To determine if these markers can predict tumor behavior and patient outcomes in vulvar SCC.

Main Methods

  • Histopathologic assessment and IHC analysis of p16, p53, and PDL1 were performed on 41 vulvar SCC samples.
  • Data were correlated with clinical and pathological characteristics, including age, depth of invasion (DOI), and lymphovascular space invasion (LVSI).

Main Results

  • The mean patient age was 72.1 years; p16 and PDL1 were positive in 24.4% and 17.1% of samples, respectively.
  • p16-positive tumors had a significantly smaller DOI (p=0.014), while abnormal p53 expression correlated with greater DOI (p=0.041).
  • PDL1 expression showed a trend towards correlation with increased inflammatory cells (p=0.055), and LVSI was associated with p16-negative status.

Conclusions

  • Contrary to some reports, the mean age of vulvar SCC patients in this cohort did not decrease.
  • p16 expression was inversely correlated with p53, and tumors with abnormal p53 and absent p16 exhibited greater DOI.
  • Findings suggest an association between PDL1 expression and increased inflammatory infiltrates in vulvar SCC, warranting further investigation.

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